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Журнал с 01.12.2015 допущен ВАК для публикации основных результатов диссертаций как издание, входящее в международные реферативные базы систем цитирования (Web Science, Scopus) (см. Vak.ed.gov.ru Перечень журналов МБД 16.03.2018г)




© 2015    Jianfeng Yu; Zhiming Liu; Xinpeng Wang; Mei Jin; Haolin Chen; Zhouyi Guo*

South China Normal University, Laboratory of Photonic Chinese Medicine, MOE Key Laboratory of Laser Life Science, College of Biophotonics, 510631, Guangzhou, Guangdong, China

Corresponding Author: E-mail:ann@scnu.edu.cn

These authors contributed equally to this work.

Polyaniline, an organic conducting polymer, exhibits strong light absorption in near-infrared region. Herein, the potential of polyaniline nanoparticles as the contrast agents for optical coherence tomography imaging was investigated. Polyaniline nanoparticles were synthesized by a facile chemical oxidative method. The optical coherence tomogra-phy images obtained from ex vivo swine liver tissues showed concentration-dependent contrast effect of polyaniline nanoparticles. Then the nanoagents were applied to in vivo optical coherence tomography imaging of tumor tissues using a xenograft tumor mouse model. The penetration depth of the optical coherence tomography signals from tumors injected with polyaniline nanoparticles was significant lower than that from tumors injected with phosphate buffer solution. The remarkable contrast effect of polyaniline nanoparticles was then quantitatively studied by the attenuation coefficients of optical coherence tomography signals. Furthermore, the permeation dynamics of polyaniline nanoparticles in tissue was also studied by Raman spectroscopy.

Keywords: polyaniline nanoparticle, optical coherence tomography, Raman spectroscopy.

OCIS codes: 160.4890, 170.1650

Submitted 15.04.2015


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