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DOI: 10.17586/1023-5086-2019-86-04-59-62
УДК: 666.189.2
Multicore large-aperture fiber-optic probe based on quartz–quartz-type lightguides for near-infrared fluorimeters
Full text «Opticheskii Zhurnal»
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Publication in Journal of Optical Technology
Шилов И.П., Даниелян Г.Л., Замятин А.А., Маковецкий А.А., Кочмарев Л.Ю. Многожильный высокоапертурный волоконно-оптический зонд на основе световодов типа кварц–кварц для флуориметров ближнего инфракрасного спектрального диапазона // Оптический журнал. 2019. Т. 86. № 4. С. 59–62. http://doi.org/10.17586/1023-5086-2019-86-04-59-62
Shilov I.P., Danielyan G.L., Zamyatin A.A., Makovetskiy A.A., Kochmarev L.Yu. Multicore large-aperture fiber-optic probe based on quartz–quartz-type lightguides for near-infrared fluorimeters [in Russian] // Opticheskii Zhurnal. 2019. V. 86. № 4. P. 59–62. http://doi.org/10.17586/1023-5086-2019-86-04-59-62
I. P. Shilov, G. L. Danielyan, A. A. Zamyatin, A. A. Makovetskiĭ, and L. Yu. Kochmarev, "Multicore large-aperture fiber-optic probe based on quartz–quartz-type lightguides for near-infrared fluorimeters," Journal of Optical Technology. 86(4), 243-245 (2019). https://doi.org/10.1364/JOT.86.000243
The optimization problem of the parameters of lightguides for fiber-optic probes used in fluorescent tumor diagnostics (of benign and malignant tumors) is considered. It has been shown that, to increase the sensitivity of a fluorimeter in the near-infrared region, it is promising to use fiber lightguides of the quartz–quartz type, with an increased numerical aperture of up to 0.30 and a biocompatible protective coating of P-12 polyamide or tetrafluoroethylene copolymer with Tefzel ethylene, as probe lightguides for detecting luminescence. Using such lightguides, a prototype version of a 19-core large-aperture fiber-optic probe for a laser oncofluorometer with increased sensitivity operating in the spectral range 900–1100 nm has been developed. The minimum dose of the injected drug was 10 μg/kg of bio-object weight, which corresponds to a world-class level of sensitivity of photosensitizer detection in biological tissues.
fiber-optic probe, fluorescent tumor diagnostics, photosensitizer, fiber lightguide
OCIS codes: 170.010:20.0220
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