Video-endoscopy system for photodynamic theranostics of central lung cancer

Papayan, G.V., Akopov, A.L., Goncharov, S.E., Struy, A.V., Kazakov, N.V.

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Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Папаян Г.В., Акопов А.Л., Гончаров С.Е., Струй А.В., Казаков Н.В. Видеоэндоскопическая система для фотодинамической тераностики центрального рака легкого // Оптический журнал. 2019. Т. 86. № 7. С. 27–34. http://doi.org/10.17586/1023-5086-2019-86-07-27-34

Papayan G.V., Akopov A.L., Goncharov S.E., Struy A.V., Kazakov N.V. Video-endoscopy system for photodynamic theranostics of central lung cancer [in Russian] // Opticheskii Zhurnal. 2019. V. 86. № 7. P. 27–34. http://doi.org/10.17586/1023-5086-2019-86-07-27-34

For citation (Journal of Optical Technology):

G. V. Papayan, A. L. Akopov, S. E. Goncharov, A. V. Struĭ, and N. V. Kazakov, "Video-endoscopy system for photodynamic theranostics of central lung cancer," Journal of Optical Technology. 86(7), 414-419 (2019). https://doi.org/10.1364/JOT.86.000414

Abstract:

Theranostics is a new medical specialization that combines therapy with diagnostics. This paper describes a video-endoscopy system intended for the photodynamic theranostics of malignant tumors of the respiratory passages, in which treatment consists of photodynamic therapy, using photosensitizers of the chlorin series (visible region) and indocyanine green (near-IR region), while diagnosis is performed using the same agents, but now as fluorescence markers of the tumor. The system is based on a standard brochofibroscope that uses several diode lasers as light sources to provide photodynamic action, to excite fluorescence, and for observation in reflected white light. Visualization is carried out by a multispectral video system that relies on the fluorescence pattern to perform targeted irradiation of the tumor and to monitor the irradiation-energy dosage from the attenuation of the photosensitizer’s luminescence brightness. The possibilities of the system are illustrated by clinical examples.

Keywords:

fluorescence endoscopy, photodynamic therapy, theranostics, lung cancer

OCIS codes: 170.0110, 170.6280

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