Optical and electrophysiological techniques for functional assessment of vision system neuronal networks

Kozub, K.E., Muravieva, S.V., Pronin, S.V.

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Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Муравьева С.В., Козуб К.Е., Пронин С.В. Оптические и электрофизиологические методы оценки функционального состояния нейронных сетей зрительной системы // Оптический журнал. 2021. Т. 88. № 12. С. 42–49. http://doi.org/10.17586/1023-5086-2021-88-12-42-49

Muravieva S.V., Kozub K.E., Pronin S.V. Optical and electrophysiological techniques for functional assessment of vision system neuronal networks [in Russian] // Opticheskii Zhurnal. 2021. V. 88. № 12. P. 42–49. http://doi.org/10.17586/1023-5086-2021-88-12-42-49

For citation (Journal of Optical Technology):

S. V. Muravieva, K. E. Kozub, and S. V. Pronin, "Optical and electrophysiological techniques for functional assessment of vision system neuronal networks," Journal of Optical Technology. 88(12), 710-715 (2021). https://doi.org/10.1364/JOT.88.000710

Abstract:

We studied the two major channels of the vision system, which differ not only in their spatial-frequency characteristics but also in the sizes of the cellular structures that support the corresponding neuronal networks. We used a combination of optical and electrophysiological techniques to measure the properties of these channels in normal test subjects and in patients with various types of cognitive impairment. For electrophysiological measurements, a digital filter was used to generate stimuli with spatial-frequency responses for selective activation of each channel. Optical coherence tomography (OCT) and electrophysiological measurements in test subjects with various types of cognitive impairment were used to determine the relationship between morphological and functional changes in the vision system channel, which is primarily formed by the small-cell neuronal network and supports processing of high spatial frequencies.

Keywords:

eyesight, optical coherence tomography, evoked potentials, retina, cognitive impairments, spatial-frequency filtering

Acknowledgements:

This work was performed with support from Government Program 47 under the Government Program for Scientific and Technical Development of the Russian Federation (2019–2030), Topic 0134-2019-0006 (Section 63.3).

OCIS codes: 330.033, 330.6110, 330.7329, 330.5380

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