Terahertz nonstationary high resolution spectroscopy: State of art and trends of development

Vaks, V.L., Domrachyova, E.G., Chernyaeva, M.B., Anfertiyev, V.A., Yablokov, A.A.

Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Вакс В.Л., Домрачева Е.Г., Черняева М.Б., Анфертьев В.А., Яблоков А.А. Терагерцовая нестационарная спектроскопия высокого разрешения: современное состояние и направления развития // Оптический журнал. 2024. Т. 91. № 1 . С. 39–48. http://doi.org/10.17586/1023-5086-2024-91-01-39-48

Vaks V.L., Domracheva E.G., Chernyaeva M.B., Anfertev V.A., Yablokov A.A. Terahertz nonstationary high resolution spectroscopy: State of art and trends of development [in Russian] // Opticheskii Zhurnal. 2024. V. 91. № 1. P. 39–48. http://doi.org/10.17586/1023-5086-2024-91-01-39-48

For citation (Journal of Optical Technology):

Vladimir L. Vaks, Elena G. Domracheva, Mariya B. Chernyaeva, Vladimir A. Anfertev, and Anton A. Yablokov, "Terahertz nonstationary high-resolution spectroscopy: state-of-the-art and trends of development," Journal of Optical Technology. 91(1), 23-28 (2024). https://doi.org/10.1364/JOT.91.000023

Abstract:

Subject of study. The chemical composition of multicomponent gas mixtures of biological origin. Aim of study. Compiling the metabolic profiles of diseases at the examples of studying the biological samples (ear-nose-throat organs tissues, urina) with high resolution terahertz spectroscopy. Method. A spectroscopy based on nonstationary effects such as inducing and decaying the free dumping polarization in a gas sample at interaction of radiation and gas molecules is a highly sensitive method of investigation the multicomponent gas mixtures. The spectrometer based on their principles operates in the modes with phase switching or fast sweeping of the probing radiation. Main results. Some experimental results of using the high resolution terahertz spectroscopy for solving the problems of medical diagnostics and the control of treatment carried out are presented in this paper. The multicomponent gas mixtures such as vapors or thermal decomposition products of various samples (biological liquids (urine) and pathological tissues of living organism) were studied using the THz nonstationary spectrometers for developing the diagnostic methods. The results of experimental data analysis allow to reveal the substances-markers for specified diseases of living organism (diabetes, pathology tissues of ear-nose-throat organs) or substances appearing at therapeutical treatment (nephrotoxical influence of chemotherapy). Practical significance. Terahertz nonstationary high resolution spectroscopy can be considered as a prospective analytical method of spectral analysis for fundamental and applied research.

Keywords:

terahertz nonstationary high resolution spectroscopy, phase switching the probing radiation, fast sweeping of the frequency of probing radiation, multicomponent gas mixture, pathology tissues of ear-nose-throat organs

Acknowledgements:

the elaboration of high resolution spectrometer with fast frequency sweep, as well as study of pathology tissues of ear-nose-throat organs was funded by the Russian Science Foundation, grant № 21-19-00357, study of biological liquids for revealing disease markers was funded by the Government Statement of work for IPM RAS FFUF -2021-0024.

OCIS codes: 300.6495, 300.1030, 300.6320

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