The effect of vaping on the optical properties of ovaries in normal conditions and in sarcoma

Selifonov, A.A., Selifonova E.I., Varlamova G.N., Tuchin, V.V.

For Russian citation (Opticheskii Zhurnal):

Селифонов А.А., Селифонова Е.И., Варламова Г.Н., Тучин В.В. Влияние жидкости для электронных сигарет на оптические свойства яичников в норме и при саркоме // Оптический журнал. 2024. Т. 91. № 10. С. 80–93. http://doi.org/10.17586/1023-5086-2024-91-10-80-93

Selifonov A.A., Selifonova E.I., Varlamova G.N., Tuchin V.V. The effect of vaping on the optical properties of ovaries in normal conditions and in sarcoma [in Russian] // Opticheskii Zhurnal. 2024. V. 91. № 10. P. 80–93. http://doi.org/10.17586/1023-5086-2024-91-10-80-93

For citation (Journal of Optical Technology):

Abstract:

Subject of study. In this study, the effect of liquids for electronic cigarettes (e-liquid) on the optical properties of normal and sarcoma ovaries was studied using reflectance spectroscopy. Aim of study. Determination of quantitative characteristics of molecular diffusion of e-liquid (70% glycerol and 30% propylene glycol) in tissues of normal feline ovaries and cat ovaries with sarcoma. Method. The optical properties of the studied samples were studied by diffuse optical reflectance and transmission spectroscopy in the spectral range from 200 to 800 nm. Main results. The diffusion effective coefficients of the test liquid for electronic cigarettes were calculated: in the tissues of normal cat ovaries D = (2.7 ± 0.4)х10–6 cm2/s, and for ovaries with sarcoma D = (2.9 ± 0.5)х10–5 cm2/s. It has been shown that during the interaction of tissue samples with e-liquids, a temporary and reversible decrease in diffuse reflection and an increase in total transmittance in relation to control samples is observed in a wide spectral range of wavelengths from deep UV to NIR, which indicates a reversible decrease in light scattering in the tissue and corresponding change in its structure. As a result of the action of the e-liquid under study, the total transmittance coefficient increases by 22 times for normal ovarian tissue in 100 minutes with a sample thickness of about 1 mm. In case of stromal sarcoma, the increase in transmission is 2 times with the same sample thickness and operating time of about 40 minutes. Practical significance. The data obtained may be useful in creating new, more effective protocols for optical endoscopic diagnostics of the reproductive system, photodynamic or photothermal therapy, and surgical interventions using a laser scalpel in the treatment of ovarian cancer. These results can also be used for cryopreservation of organs, including organs of the human reproductive system, since glycerin and propylene glycol are used in cryobiology.

Keywords:

ovarian tissue, liquid for electronic cigarettes, optical properties, total transmittance spectra, diffuse reflectance spectra, diffusion coefficient, efficiency of optical clearing

Acknowledgements:

the work was supported by the RSF Grant № 23-14-00287

OCIS codes: 300.0300

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