УДК: 651.849.19
Optical method and apparatus for detoxicating the poisonous action of carbon monoxide
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Асимов М.М., Асимов Р.М., Плавский В.Ю., Краснобаев А.Б., Владимиров Д.Б., Рубинов А.Н. Оптический метод и аппаратура для дезинтоксикации отравляющего действия угарного газа // Оптический журнал. 2013. Т. 80. № 8. С. 3–8.http://doi.org/10.17586/1023-5086-2022-89-01-82-91
Asimov M. M., Plavskiĭ V. Yu., Krasnobaev A. B., Vladimirov D. B., Rubinov A. N., and AsimovR. M. Optical method and apparatus for detoxicating the poisonous action of carbon monoxide // Opticheskii Zhurnal. 2013. V. 80. №8. P. 3–8.
This paper proposes and discusses a fundamentally new approach to eliminating the poisonous action of carbon monoxide. A technology based on the phenomenon of laser-induced photodissociation of carboxyhemoglobin in the blood vessels and capillaries has been developed. The spectra of the action of carboxyhemoglobin and oxyhemoglobin in the cutaneous blood vessels are calculated by numerically modeling the interaction of laser radiation with biological tissue. Criteria are determined for the efficiency of the induced photodissociation of carboxyhemoglobin when the radiation acts directly on the pulmonary alveoli, through the epidermis, and intravenously.
carboxyhemoglobin, photodissociation, oxyhemoglobin, hemoglobin, carbon monoxide intoxication, phototherapy
OCIS codes: 350.4600, 300, 6360
References:1. T. Meredith and A. Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
2. J. E. Peterson and R. D. Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
3. W. J. Egan, W. E. Brewer, and S. L. Morgan, “Measurements of carboxyhemoglobin in forensic blood samples using UV–visible spectrometry and improved principal component regression,” Appl. Spectrosc. 53, 218 (1999).
4. M. Goulon, A. Barois, M. Rapin, F. Nouailat, S. Grosbuis, and J. Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).
5. P. Croker, “Carbon monoxide poisoning: the clinical entity and its treatment. A review,” Mil. Med. 149, 257 (1984).
6. P. S. Grim, L. J. Gottlieb, A. Boddie, and E. Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
7. C. Piantadosi, “The role of hyperbaric oxygen in carbon monoxide, cyanide and sulfide intoxications,” Probl. Respir. Care 4, 215 (1991).
8. P. M. Tibbles and J. S. Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
9. B. M. Dzhagarov, V. S. Chirvonyı˘, and G. P. Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S. Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.
10. W. A. Saffran and Q. H. Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).
11. V. F. Kramerenko, Yu. A. Sobchuk, and T. N. Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxy hemoglobin and Carboxymyoglobin (Moscow, 1974).
12. M. M. Asimov, R. M. Asimov, and A. N. Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
13. M. M. Asimov, R. M. Asimov, and A. N. Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).
14. M. M. Asimov, R. M. Asimov, and A. N. Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).