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УДК: 621.391.837.681.3]:[621, 681:723
System for fluorescence diagnosis and photodynamic therapy of cervical disease
Full text «Opticheskii Zhurnal»
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Publication in Journal of Optical Technology
U. Kang, Папаян Г.В., Обухова Н.А., S. J. Bae, D. S. Lee, M. W. Jung, Березин В.Б., Мотыко А.А., Плохих Д.П., Слободенюк С.А. Комплекс для флуоресцентной диагностики и фотодинамической терапии заболеваний шейки матки // Оптический журнал. 2015. Т. 82. № 12. С. 47–59.
U. Kang, Papayan G.V., Obukhova N.A., S. J. Bae, D. S. Lee, M. W. Jung, Berezin V.B., Motyko A.A., Plokhikh D.P., Slobodenyuk S.A. System for fluorescence diagnosis and photodynamic therapy of cervical disease [in Russian] // Opticheskii Zhurnal. 2015. V. 82. № 12. P. 47–59.
U. Kang, G. V. Papayan, N. A. Obukhova, S. J. Bae, D. S. Lee, M. W. Jung, V. B. Berezin, A. A. Motyko, D. P. Plokhikh, and S. A. Slobodenyuk, "System for fluorescence diagnosis and photodynamic therapy of cervical disease," Journal of Optical Technology. 82(12), 815-823 (2015). https://doi.org/10.1364/JOT.82.000815
This system is designed for development of fluorescence diagnosis and photodynamic therapy methods for cervical pathologies. Diagnosis is performed on the basis of multispectral autofluorescence images obtained using various types of excitation, as well as images in reflected white light after exposure to acetic acid. Said diagnosis is performed using an expert system for automatic recognition of cervical neoplasms; this expert system has been validated using verified images obtained from 151 patients. Based on test results, a sensitivity of 0.85–0.95 and specificity of 0.78–0.97 are obtained, depending on the scope of the differential diagnosis. It is shown that fluorescence images can be used to monitor photodynamic therapy.
colposcopy, cervical cancer, fluorescence diagnostics, autofluorescence, photodynamic therapy, computer vision
Acknowledgements:The authors thank the Seoul Metropolitan Government and the Seoul Development Institute for their support of this work within the framework of the international program “Inviting & Supporting Project of Global Leading Institutions” (funds WR100001 for Russia Science Seoul). They also thank Jeong-Yeol Park (Asian Medical Center) for careful preparation of the material used in the autofluorescence diagnosis database and A. R. Khachaturyan (D. O. Ott Scientific Research Institute for Obstetrics and Gynecology) for medical consultations and development of photodynamic therapy techniques. This work was performed with the support of the Russian Foundation for Basic Research (RFFI) (Grant 15-07-00188).
OCIS codes: 170.0170, 170.3880, 170.3890, 170.4580
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