Solid-phase photosensitizers based on fullerene C60 for photodynamic inactivation of viruses in biological liquids

Белоусова И.М., Данилов О.Б., Муравьева Т.Д., Кисляков И.М., Рыльков В.В., Крисько Т.К., Киселев О.И., Зарубаев В.В., Сироткин А.К., Пиотровский Л.Б. Твердофазные фотосенсибилизаторы на основе фуллерена С60 для фотодинамической инактивации вирусов в биологических жидкостях // Оптический журнал. 2009. Т. 76. № 4. С. 97–107.

Belousova I.M., Danilov O.B., Muravieva T.D., Kislyakov I.M., Rylkov V.V., Krisko T.K., Kiselev O.I., Zarubaev V.V., Sirotkin A.K., Piotrovskiy L.B. Solid-phase photosensitizers based on fullerene C60 for photodynamic inactivation of viruses in biological liquids [in Russian] // Opticheskii Zhurnal. 2009. V. 76. № 4. P. 97–107.

I. M. Belousova, O. B. Danilov, T. D. Murav’eva, I. M. Kiselyakov, V. V. Ryl’kov, T. K. Kris’ko, O. I. Kiselev, V. V. Zarubaev, A. K. Sirotkin, and L. B. Piotrovskiĭ, "Solid-phase photosensitizers based on fullerene C₆₀ for photodynamic inactivation of viruses in biological liquids," Journal of Optical Technology. 76 (4), 243-250 (2009). https://doi.org/10.1364/JOT.76.000243

A new type of solid-phase photosensitizer has been proposed and created on the basis of aggregated fullerene C60 for the photodynamic inactivation of pathogens in biological liquids. This paper demonstrates the chief advantage of such solid-phase systems, which is that efficient inactivation of pathogens (using influenza viruses as an example) by active forms of oxygen formed when a photosensitizer is irradiated in aqueous and biological media is combined with high photostability of the fullerene coatings and the possibility of completely extracting the photosensitizer from the biological medium after photodynamic activation.