УДК: 535.343.4 + 535-14

Using the methods and facilities of nonsteady-state spectroscopy of the subterahertz and terahertz frequency ranges for noninvasive medical diagnosis

Vaks, V.L., Domrachyova, E.G., Maslennikova A.V., Sobakinskaya Е.А., Chernyaeva, M.B.

Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Вакс В.Л., Домрачева Е.Г., Масленникова А.В., Собакинская Е.А., Черняева М.Б. Применение методов и средств нестационарной спектроскопии субтерагерцовых и терагерцовых диапазонов частот для неинвазивной медицинской диагностики // Оптический журнал. 2012. Т. 79. № 2. С. 9–14.

Vaks V. L., Domracheva E. G., Sobakinskaya E. A., Chernyaeva M. B., Maslennikova A. V. Using the methods and facilities of nonsteady-state spectroscopy of the subterahertz and terahertz frequency ranges for noninvasive medical // Opticheskii Zhurnal. 2012. V. 79. № 2. P. 9–14.

For citation (Journal of Optical Technology):

V. L. Vaks, E. G. Domracheva, E. A. Sobakinskaya, M. B. Chernyaeva, and A. V. Maslennikova, "Using the methods and facilities of nonsteady-state spectroscopy of the subterahertz and terahertz frequency ranges for noninvasive medical diagnosis," Journal of Optical Technology. 79(2), 66-69 (2012). https://doi.org/10.1364/JOT.79.000066

Abstract:

This paper discusses ways to implement terahertz-range spectrometers based on the effects of freely damped polarization and rapid traverse of the frequency range. It presents the results of using developed spectrometers to record the presence of ammonia, acetone, and nitric oxide in exhaled air, as well as to analyze a liquid (Custodiol) for flushing transplanted parenchymatous organs.

Keywords:

noninvasive medical diagnostics, transient terahertz spectroscopy, phase-modulation spectrometer of gas-acting radiation, exhaled air, marker molecule, custodiol

OCIS codes: 300.6495, 300.6390, 170.6510

References:

1. E. V. Stepanov, “Methods of high-sensitivity gas analysis of biomarker molecules in studies of exhaled air,” Trudy Inst. Obshch. Fiz. 61, 5 (2005).
2. V. A. Skrupski˘ı, “Endogenous volatile compounds—biological markers in human physiology and pathology—and methods of determining them,” Nauch. Tekhnich. Otchet. Inst. Okeanol. (1994).
3. M. Phillips, “Breath tests in medicine,” Sci. Am. 267, No. 1, 74 (1992).
4. T. Higenbottam, “Lung disease and pulmonary endothelial nitric oxide,” Exp. Physiol. 80, 855 (1995).
5. K. Alving, E. Weitzberg, and J. M. Lundberg, “Increased amount of nitric oxide in exhaled air of asthmatics,” Eur. Respir. J. 6, 1368 (1993).
6. D. R. Taylor, M. W. Pijnenburg, A. D. Smith, and J. C. D. Jongste, “Exhaled nitric oxide measurements: clinical application and interpretation,” Thorax 61, 817 (2006).
7. I. I. Dedov and M. V. Shestakova, Diabetes Mellitus (Universum Pub., Moscow, 2003).
8. I. I. Dedov, M. I. Balabolkin, and E. M. Klebanova, Diabetes Mellitus: Pathogenesis, Classification, Diagnosis, and Treatment: A Manual for Physicians (Moscow, 2003).
9. C. R. Kahn, Joslin’s Diabetes Mellitus (Lippincott Williams & Wilkins, Philadelphia, 2005).
10. V. G. Berezkin, Gas–Liquid–Solid-Phase Chromatography (Khimiya, Moscow, 1986).
11. S. Kage, K. Kudo, and N. Ikeda, “Determination of nitrate in blood by gas chromatography and gas chromatography–mass spectrometry,” J. Chromatogr., B: Biomed. Appl. 742, 363 (2000).
12. M. Larstad, C. Loh, G. Ljungkvist, A. C. Olin, and K. Toren, “Determination of ethane, pentane and isoprene in exhaled air using a multi-bed adsorbent and end-cut gas–solid chromatography,” Analyst 127, 1440 (2002).
13. B. A. Mamyrin, “Time-of-flight mass spectrometry (concepts, achievements, and prospects),” Int. J. Mass. Spectrom. 206, 251 (2001).
14. W. A. Carrick, D. B. Cooper, and B. Muir, “Retrospective identification of chemical warfare agents by high-temperature automatic thermal desorption–gas chromatography–mass spectrometry,” J. Chromatogr. A 925, 241 (2001).
15. S. S. Kharintsev, G. G. Hoffmann, J. Loos, G. De With, P. S. Dorozhkin, and M. Kh. Salakhov, “Subwavelength-resolution near-field Raman spectroscopy,” J. Exp. Theor. Phys. 105, 909 (2007).
16. J. Zheng, Zh. Tang, Y. He, and L. Guo, “Sensitive detection of weak absorption signals in photoacoustic spectroscopy by using derivative spectroscopy and wavelet transform,” J. Appl. Phys. 103, 093116 (2008).
17. M. B. Pushkarsky, M. E. Webber, and C. K. N. Patel, “Ultra-sensitive ambient ammonia detection using CO2-laser-based photoacoustic spectroscopy,” Appl. Phys. B: Lasers Opt. 77, 381 (2003).
18. W.-B. Yan, “Trace gas analysis by diode laser cavity ring-down spectroscopy,” Proc. SPIE 4648, 156 (2002).
19. J. Feng, M. Raynor, and Yu. Chen, “Spectroscopy exposes trace-water contamination in process gases,” Technology Equipment Update. Compound Semiconductor, October 2007, pp. 31–33.
20. V. L. Vaks, A. B. Brailovsky, and V. V. Khodos, “Millimeter range spectrometer with phase switching—Novel method for reaching of the top sensitivity,” Int. J. Infrared Millim. Waves 20, 883 (1999).
21. V. L. Vaks, V. V. Khodos, and E. V. Spivak, “A nonstationary microwave spectrometer,” Rev. Sci. Instrum. 70, 3447 (1999).
22. V. V. Khodos, D. A. Ryndyk, and V. L. Vaks, “Fast-passage microwave molecular spectroscopy with frequency sweeping,” J. Appl. Phys. 25, 203 (2004).
23. V. L. Vaks, E. G. Domracheva, S. D. Nikiforov, E. A. Sobakinskaya, and M. B. Chernyaeva, “The use of microwave nonsteady-state spectroscopy for noninvasive medical diagnosis,” Izv. Vyssh. Uchebn. Zaved. Radiofiz. 51, 490 (2008).
24. V. L. Vaks, A. N. Panin, S. A. Basov, A. V. Illyuk, S. I. Pripolzin, D. G. Pavel’ev, and Yu. I. Koshurinov, “Nonsteady-state spectroscopy of the 1–2.5-THz range on solid-state devices,” Izv. Vyssh. Uchebn. Zaved. Radiofiz. 52, 569 (2009).
25. V. L. Vaks, Yu. I. Koshurinov, D. G. Pavel’ev, and A. N. Panin, “The development and creation of a system for phase synchronization in the subterahertz and terahertz frequency ranges using the harmonic of the signal of the synthesizer of the centimeter range,” Izv. Vyssh. Uchebn. Zaved. Radiofiz. 48, 933 (2005).
26. V. L. Vaks, A. N. Panin, D. G. Paveliev, and U. I. Koshurinov, “Generation of high stable wide-range THz radiation for precise frequency measurements,” in Proc. of the 33rd International Conference on Infrared, Millimeter and Terahertz Waves, Pasadena, California, USA, 2008, M4B3, p. 1560.
27. V. L. Vaks, E. G. Domracheva, S. D. Nikiforov, E. A. Sobakinskaya, and M. B. Chernyaeva, “Method of microwave nonsteady-state gas spectroscopy for noninvasive medical diagnosis,” Biomed. Tekhnol. Radio´elek. 5, 9 (2008).
28. M. S. Sagar, G. Singh, D. I. Hodson, and A. C. Whitton, “Nitric oxide and anti-cancer therapy,” Cancer Treat. Rev. 21, 159 (1995).