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ISSN: 1023-5086

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ISSN: 1023-5086

Scientific and technical

Opticheskii Zhurnal

A full-text English translation of the journal is published by Optica Publishing Group under the title “Journal of Optical Technology”

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DOI: 10.17586/1023-5086-2023-90-01-60-75

УДК: 535.51, 535.361, 616.15-07

Polarization non-invasive method of blood hematocrit monitoring

Khlynov, R.D., Ryzhova, V.A., Korotaev, V.V., Yarishev S.N., Djamiykov, T.S., Marinov, M.B.

Full text on elibrary.ru

Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Хлынов Р.Д., Рыжова В.А., Коротаев В.В., Ярышев С.Н., Джамийков Т.С., Маринов М.Б. Поляризационный неинвазивный метод мониторинга гематокрита крови // Оптический журнал. 2023. Т. 90. № 1. С. 60–75. http://doi.org/10.17586/1023-5086-2023-90-01-60-75

 

Khlynov R.D., Ryzhova V.A., Korotaev V.V., Yarishev S.N., Djamiykov T.S., Marinov M.B. Polarization non-invasive method of blood hematocrit monitoring [in Russian] // Opticheskii Zhurnal. 2023. V. 90. No 1. P. 60–75. http://doi.org/10.17586/1023-5086-2023-90-01-60-75

For citation (Journal of Optical Technology):

R. D. Khlynov, V. A. Ryzhova, V. V. Korotaev, S. N. Yarishev, T. S. Djamiykov, and M. B. Marinov, "Noninvasive polarization-based technique for hematocrit monitoring," Journal of Optical Technology. 90(1), 33-41 (2023). https://doi.org/10.1364/JOT.90.000033

Abstract:

Subject of study. Polarization images, corresponding to the coordinate distributions of the polarization state parameters of optical radiation scattered by biological objects, which are characterized by different levels of blood hematocrit.  Polarization images were formed as a result of probing laser radiation with a given state of polarization of blood-containing tissue through the fingernail plate of the little finger of the person’s left hand. Purpose of work. To analyze the possibilities of using the active video polarimetry method for non-contact monitoring of blood hematocrit in real time. To develop the informative criteria for determination the difference in the level of blood hematocrit in different states of a biological object, this work was carried out. Method. Physical modeling of transformation of the polarized radiation parameters during its interaction with a biological object. An optical scheme of the Stokes Video Polarimeter layout for irradiance distributions recording on the sensitive area of matrix photodetector with a single field of analysis was implemented. Digital images processing using Stokes and Mueller matrix formalism was performed. Comparative statistical analysis of the coordinate distributions of light polarization state parameters (degree of polarization, azimuth and ellipticity) was carried out to identify the possibility to determine differences in the hematocrit level in human blood. Main results. A new approach to non-invasive blood hematocrit level monitoring based on the polarization-optical method was proposed. We obtained coordinate distributions and histograms of the light polarization state parameters for two participating volunteers, whose body states are guaranteed to differ by the blood hematocrit level. Statistical analysis was performed, which showed that significant differences in the statistical moments of the second–fourth orders of light polarization parameters are the most informative diagnostic indicators in the comparative analysis of biological objects with different blood hematocrit levels. Practical significance. With further development, the proposed method can find application in both medical diagnostics and therapy in emergency situations. Timely detection of significant deviations from normal hematocrit based on automated calculation and analysis of the developed informative criteria will allow continuous monitoring of blood hematocrit during surgical operations and effective real-time correction of blood viscosity.

 

Acknowledgment: the authors are grateful to the Research Center for Optoelectronic Instrumentation of St. Petersburg University ITMO and Research and Development Sector of the Technical University of Sofia for material and financial support.

Keywords:

polarization, blood hematocrit, scattering, Stokes vector, polarization images, coordinate distributions, statistical analysis

OCIS codes: 120.5410, 120.0120, 110.5405

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