ru/ ru

ISSN: 1023-5086


ISSN: 1023-5086

Scientific and technical

Opticheskii Zhurnal

A full-text English translation of the journal is published by Optica Publishing Group under the title “Journal of Optical Technology”

Article submission Подать статью
Больше информации Back

УДК: 534.615, 535.015, 617.7, 617.735

Real-time optoacoustic monitoring of the temperature of the retina during laser therapy

For Russian citation (Opticheskii Zhurnal):

Серебряков В.А., Бойко Э.В., Ян А.В. Оптико-акустический мониторинг температуры сетчатки при лазерной терапии в режиме реального времени // Оптический журнал. 2014. Т. 81. № 6. С. 14–26.


Serebryakov V.A., Boyko E.V., Yan A.V. Real-time optoacoustic monitoring of the temperature of the retina during laser therapy [in Russian] // Opticheskii Zhurnal. 2014. V. 81. № 6. P. 14–26.

For citation (Journal of Optical Technology):

V. A. Serebryakov, É. V. Boĭko, and A. V. Yan, "Real-time optoacoustic monitoring of the temperature of the retina during laser therapy," Journal of Optical Technology. 81(6), 312-321 (2014).


Laser coagulation of the retina carries risk of damaging the neuroretina because of variation of the beam power and of the local pigmentation of the retinal pigmented epithelium and the choroid. The degree of coagulation depends on the induced temperature rise and the exposure time. Laser retinotherapy with optoacoustic monitoring of the temperature provides reproducible ophthalmologically invisible (subthreshold) damage of the retina in a wide range of laser power, regardless of local changes of the tissue structure. Optoacoustic temperature measurements are based on the excitation of a pressure wave in the retinal tissue by repeated low-energy probe laser pulses. The amplitude of the pressure signal, which can be detected by means of an acoustic transducer incorporated in a laser contact lens, correlates with the temperature of the tissue. This paper discusses promising directions of the use in clinical practice of real-time optoacoustic temperature monitoring of the retina during laser therapy in various irradiation regimes.


photocoagulator, retina, optoacoustic temperature measurements, real time mode, probing laser pulse

OCIS codes: 170.1020, 170.1065, 170.3890, 190.4870


1. A. M. Shah, N. M. Bressler, and L. M. Jampol, “Does laser still have a role in the management of retinal vascular and neovascular diseases?” Am. J. Ophthalmol. 152, 332 (2011).
2. S. Koinzer, K. Schlott, L. Ptaszynski, M. Bever, S. Kleemann, M. Saeger, A. Baade, A. Caliebe, Y. Miura, R. Birngruber, R. Brinkmann, and J. Roider, “Temperature-controlled retinal photocoagulation—a step toward automated laser treatment,” Invest. Ophthalmol. Vis. Sci. 53, 3605 (2012).
3. J. Lock and K. Fong, “An update on retinal laser therapy,” Clin. Exp. Optom. 94, No. 1, 43 (2011).
4. M. S. Blumenkranz, D. Yellachich, D. E. Andersen, M. W. Wiltberger, D. Mordaunt, G. R. Marcellino, and D. Palanker, “Semiautomated patterned scanning laser for retinal photocoagulation,” Retina 26, 370 (2006).
5. J. Langejürgen, K. Schlott, M. Bever, K. Hausmann, S. Koinzer, L. Ptaszynski, J. Roider, R. Birngruber, and R. Brinkmann, “Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation,” Proc. SPIE 7373, 73730K (2009).
6. B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Real-time microscopic visualization of tissue response to laser thermal therapy,” J. Biomed. Opt. 12, 020501 (2007).
7. G. Schüle, G. Huttmann, J. Roider, C. Wirbelauer, R. Bimgruber, and R. Brinkmann, “Optoacoustic measurements during μs irradiation of the retinal pigment epithelium,” Proc. SPIE 3914, 230 (2000).
8. K. V. Larin, I. V. Larina, M. Motamedi, and R. O. Esenaliev, “Monitoring of temperature distribution in tissues with optoacoustic technique in real time,” Proc. SPIE 3916, 311 (2000).
9. M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt. 14, 054024 (2009).
10. L. M. Lyamshev, “Lasers in acoustics,” Usp. Fiz. Nauk 151, 479 (1987) [Sov. Phys. Usp. 30, 252 (1987)].
11. R. Brinkmann, S. Koinzer, K. Schlott, L. Ptaszynski, M. Bever, A. Baade, S. Luft, Y. Miura, R. Birngruber, and J. Roider, “Real-time temperature determination during retinal photocoagulation on patients,” Proc. SPIE 7885, 78850 (2011).
12. K. V. Larin, I. V. Larina, and R. O. Esenaliev, “Monitoring of tissue coagulation during thermal therapy using optoacoustic technique,” J. Phys. D 38, 2645 (2005).
13. M. G. Arsenault, M. C. Kolios, and W. M. Whelan, “Optoacoustic detection of thermal lesions,” Proc. SPIE 7177, 71771V (2009).
14. A. A. Oraevsky, “Laser-induced acoustic and shock waves in ocular tissues,” Tech. Rep. AL/OE-TR-1995-0044 (Armstrong Laboratory, Brooks AFB, Tex., 1995).
15. A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation,” Chem. Rev. 103, 577 (2003).
16. G. Schüle, “Mechanismen und On-line Dosimetrie bei selektiver RPE Therapie,” Dissertation (Lübeck Univ., 2003).
17. J. Cannata, Q. Zhou, J. Williams, J. Yen, C. Hu, and K. Shung, Development of high frequency ultrasound transducers for medical imaging, Biomedical Engineering Department, University of Southern California, 2008.
18. G. Schüle, H. Elsner, H. Hoerauf, C. Framme, J. Roider, H. Elsner, R. Birngruber, and R. Brinkmann, “OA online dosimetry during selective RPE treatment,” Proc. SPIE 5314, 286 (2004).
19. Y. M. Paulus, A. Jain, H. Nomoto, C. Sramek, R. F. Gariano, D. Andersen, G. Schuele, L. Leung, T. Leng, and D. Palanker, “Selective retinal therapy with microsecond exposure using a continuous line scanning laser,” Retina 31, 380 (2011).
20. J. Kandulla, H. Elsner, M. Hilmes, C. Hartert, R. Birngruber, and R. Brinkmann, “OA temperature determination at the fundus of the eye during transpupillary thermotherapy,” Proc. SPIE 5688, 208 (2005).
21. J. Kandulla, H. Elsner, R. Birngruber, and R. Brinkmann, “Noninvasive OA online retinal temperature determination during continuous-wave laser irradiation,” J. Biomed. Opt. 11, 041111 (2006).
22. A. Baade, K. Schlott, S. Luft, L. Ptaszynski, M. Bever, R. Birngruber, and R. Brinkmann, “Accuracy of real-time OA temperature determination during retinal photocoagulation,” Proc. SPIE 8092, 80921B (2011).
23. K. Schlott, S. Koinzer, A. Baade, R. Birngruber, J. Roider, and R. Brinkmann, “Temperature controlled retinal photocoagulation,” Proc. SPIE 8800, 880009 (2013).
24. H. H. Müller, L. Ptaszynski, K. Schlott, C. Debbeler, M. Bever, S. Koinzer, R. Birngruber, R. Brinkmann, and G. Hüttmann, “Imaging thermal expansion and retinal tissue changes during photocoagulation by high-speed OCT,” Biomed. Opt. Express. 3, 1025 (2012).