УДК: 539.1.04

The influence of terahertz radiation on the cell’s genetic apparatus

Fedorov, V.I., Serdyukov, D.S., Cherkasova, O.P., Popova, S.S., Nemova, E.F.

Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Фёдоров В.И., Сердюков Д.С., Черкасова О.П., Попова С.С., Немова Е.Ф. Влияние терагерцового излучения на генетический аппарат клетки. Обзор // Оптический журнал. 2017. Т. 84. № 8. С. 9–15.

Fedorov V.I., Serdyukov D.S., Cherkasova O.P., Popova S.S., Nemova E.F. The influence of terahertz radiation on the cell’s genetic apparatus [in Russian] // Opticheskii Zhurnal. 2017. V. 84. № 8. P. 9–15.

For citation (Journal of Optical Technology):

V. I. Fëdorov, D. S. Serdyukov, O. P. Cherkasova, S. S. Popova, and E. F. Nemova, "The influence of terahertz radiation on the cell’s genetic apparatus," Journal of Optical Technology. 84(8), 509-514 (2017). https://doi.org/10.1364/JOT.84.000509

Abstract:

This article presents a review of the literature data and our own data concerning the effects of terahertz radiation on the state of DNA, the chromosome, and the activity of genes in the cells of micro-organisms and eukaryotes. The phenotypical changes that accompany the irradiation of intact organisms are described. Mutagenic effects and epigenetic pathways of action are considered. Possible mechanisms of the nonthermal action of terahertz radiation are discussed.

Keywords:

terahertz radiation, biological effects, genes, nonthermal action

Acknowledgements:

This article is dedicated to the memory of Professor Vyacheslav Ivanovich Fëdorov, who made an outstanding contribution to the study of the interaction of THz radiation with biological objects of different levels of organization.

OCIS codes: 140.3070; 140.3330; 170.1420

References:

1. V. I. Fedorov, S. S. Popova, and A. N. Pisarchik, “Dynamic effects of submillimeter wave radiation on biological objects of various levels of organization,” Infrared Millimeter Waves 24(8), 1235–1254 (2003).

2. O. A. Ramundo and G.-P. Gallerano, “Terahertz radiation effects and biological applications,” J. Infrared, Millimeter, Terahertz Waves 30, 1308–1318 (2009).
3. V. I. Fedorov, “Study of the biological effects of electromagnetic radiation of the submillimeter part of the terahertz range,” Biomed. Radioelektron. (2), 17–27 (2011).
4. G. J. Wilmink and J. E. Grundt, “Invited review article: current state of research on biological effects of terahertz radiation,” J. Infrared, Millimeter, Terahertz Waves 32(10), 1074–1122 (2011).
5. V. I. Fedorov, “New achievements in the study of the biological efficiency of electromagnetic radiation of the submillimeter part of the THz range,” Biomed. Radioelektron. 3(63), 5–17 (2011).
6. P. Weightman, “Prospects for the study of biological systems with high-power sources of terahertz radiation,” Phys. Biol. 9(5), 053001 (2012).
7. A. A. Angeluts, A. B. Gapeev, M. N. Esaulkov, O. G. Kosareva, S. N. Matyunin, M. M. Nazarov, T. N. Pashovkin, P. M. Solyankin, O. P. Cherkasova, and A. P. Shkurinov, “Study of terahertz-radiation-induced DNA damage in human blood leukocytes,” Quantum Electron. 44(3), 247–251 (2014) [Kvant. Elektron. (Moscow) 44(3), 247–251 (2014)].
8. L. Zhao, Y.-H. Hao, and R.-Y. Peng, “Advances in the biological effects of terahertz wave radiation,” Military Med. Res. 1(26), 1–4 (2014).
9. V. I. Fedorov, “Biological danger of terahertz radiation,” Biomed. Radioelektron. (1), 34–41 (2014).
10. M. Borovkova, M. Serebriakova, V. Fedorov, E. Sedykh, V. Vaks, A. Lichutin, A. Salnikova, and M. Khodzitsky, “Investigation of terahertz radiation influence on rat glial cells,” Biomed. Opt. Express 8(1), 273–280 (2017).
11. H. Hintzsche and H. Stopper, “Effects of terahertz radiation on biological systems,” Crit. Rev. Environ. Sci. Technol. 42, 2408–2434 (2012).
12. V. I. Fedorov, N. Ya. Vaı˘sman, E. F. Nemova, A. A. Mamrashev, and N. A. Nikolaev, “The effect of terahertz radiation on the number and development dynamics of the progeny of F1 stressed drosophila females,” Biofizika 58(6), 1043–1050 (2013).
13. V. I. Fedorov, N. Ya. Weisman, E. F. Nemova, and N. A. Nikolaev, “Terahertz radiation influence on stressed drosophila life span,” Biophysics 59(3), 458–463 (2014).
14. V. I. Fedorov and N. Ya. Weisman, “The lifespan of the F1 progeny of drosophila females exposed to terahertz radiation of low intensity,” Biophysics 60(5), 835–842 (2015).
15. K.-T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W.-Y. Park, and G.-S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
16. A. B. Gapeev, N. A. Romanova, and N. K. Chemeris, “Structural changes of the chromatin of lymphoid cells under the action of low-intensity ultrahigh-frequency electromagnetic radiation on the background of an inflammatory process,” Biofizika 56(4), 688–695 (2011).
17. M. V. Tsurkan, I. V. Kudryavtsev, M. K. Serebryakova, Yu. S. Nesgovorova, I. V. Nazarova, A. S. Trulev, O. A. Smolyanskaya, V. G. Bespalov, and A. V. Polevshchikov, “Study of the action of broad-band terahertz radiation on the functional activity of cells,” J. Opt. Technol. 80(11), 655–660 (2013) [Opt. Zh. 80(11), 16–23 (2013)].
18. O. Zeni, G. P. Gallerano, A. Perrotta, M. Romanò, A. Sannino, M. Sarti, M. D’Arienzo, A. Doria, E. Giovenale, A. Lai, G. Messina, and M. R. Scarfì, “Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study,” Health Phys. 92, 349–357 (2007).
19. A. N. Bogomazova, E. M. Vassina, T. N. Goryachkovskaya, V. M. Popik, A. S. Sokolov, N. A. Kolchanov, M. A. Lagarkova, S. L. Kiselev, and S. E. Peltek, “No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation,” Sci. Rep. 5(7749), 1–6 (2015).
20. E. V. Demidova, T. N. Goryachkovskaya, T. K. Malup, S. V. Bannikova, A. I. Semenov, N. A. Vinokurov, N. A. Kolchanov, V. M. Popik, and S. E. Peltek, “Studying the non-thermal effects of terahertz radiation on E. coli/pKatG-GFP biosensor cells,” Bioelectromagnetics 34(1), 15–21 (2013).
21. E. V. Demidova, T. N. Goryachkovskaya, I. A. Mescheryakova, T. K. Malup, A. I. Semenov, N. A. Vinokurov, N. A. Kolchanov, V. M. Popik, and S. E. Peltek, “Impact of terahertz radiation on stress-sensitive genes of E. coli cell,” IEEE Trans. Terahertz Sci. Technol. 6, 435–441 (2016).
22. G. J. Wilmink, J. I. Grundt, C. Cerna, C. C. Roth, M. A. Kuipers, D. Lipscomb, I. Echchgadda, and B. L. Ibey, “Terahertz radiation preferentially activates the expression of genes responsible for the regulation of plasma membrane properties,” in International Conference on Infrared, Millimeter, and Terahertz Waves (2011).
23. J. E. Grundt, C. Cerna, C. C. Roth, B. L. Ibey, D. Lipscomb, I. Echchgadda, and G. J. Wilmink, “Terahertz radiation triggers a signature gene expression profile in human cells,” in International Conference on Infrared, Millimeter, and Terahertz Waves (2011).
24. G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, and W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Lasers Surg. Med. 7562, 75620L (2010).
25. G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, and W. P. Roach, “In vitro investigation of the biological effects associated with human dermal fibroblasts exposed to 2.52-THz radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
26. I. Echchgadda, J. E. Grundt, C. Z. Cerna, C. C. Roth, B. L. Ibey, and G. J. Wilmink, “Terahertz stimulate specific signaling pathways in human cells,” in International Conference on Infrared, Millimeter, and Terahertz Waves (2014).
27. I. Echchgadda, C. Z. Cerna, M. A. Sloan, D. P. Elam, and B. L. Ibey, “Effects of different terahertz frequencies on gene expression in human keratinocytes,” Proc. SPIE 9321, 93210Q (2015).
28. B. S. Alexandrov, K. O. Rasmussen, A. R. Bishop, A. Usheva, L. B. Alexandrov, S. Chong, Y. Dagon, L. G. Booshehri, C. H. Mielke, M. L. Phipps, J. S. Martinez, H. T. Chen, and G. Rodriguez, “Non-thermal effects of terahertz radiation on gene expression in mouse stem cells,” Biomed. Opt. Express. 2(9), 2679–2689 (2011).
29. B. S. Alexandrov, M. L. Phipps, L. B. Alexandrov, L. G. Booshehri, A. Erat, J. Zabolotny, C. H. Mielke, H. T. Chen, G. Rodriguez, K. O. Rasmussen, J. S. Martinez, A. R. Bishop, and A. Usheva, “Specificity and heterogeneity of terahertz radiation effect on gene expression in mouse mesenchymal stem cells,” Sci. Rep. 3(1184), 1–8 (2013).
30. L. V. Titova, A. K. Ayesheshim, A. Golubov, R. Rodriguez-Juarez, R. Woycicki, F. A. Hegmann, and O. Kovalchuk, “Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?” Sci. Rep. 3(2363), 1–6 (2013).
31. L. V. Titova, A. K. Ayesheshim, A. Golubov, R. Rodriguez-Juarez, A. Kovalchuk, F. A. Hegmann, and O. Kovalchuk, “Intense picosecond THz pulses alter gene expression in human skin tissue in vivo,” Sci. Rep. 3(2363), 1–6 (2013).
32. L. V. Titova, A. K. Ayesheshim, A. Golubov, D. Fogen, R. Rodriguez-Juarez, F. A. Hegmann, and O. Kovalchuk, “Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue,” Biomed. Opt. Express 4(4), 559–568 (2013).
33. G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, and W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene-expression signatures,” Opt. Interact. Tissues Cells 21, 75620K (2010).
34. J. Bock, Y. Fukuyo, S. Kang, M. L. Phipps, L. B. Alexandrov, K. O. Rasmussen, A. R. Bishop, E. D. Rosen, J. S. Martinez, H. T. Chen, G. Rodriguez, B. S. Alexandrov, and A. Usheva, “Mammalian stem cells reprogramming in response to terahertz radiation,” PLoS One 5(12), e15806 (2010).
35. V. N. Bingi, Principles of Electromagnetic Biophysics (Fizmatlit, Moscow, 2011).
36. R. Ya. Il’enkov, O. N. Prudnikov, A. V. Tachenachev, and V. I. Yudin, “Quantum theory of laser cooling: statistical description of the processdynamics,” JETP 123(1), 1–11 (2016) [Zh. Eksp. Teor. Fiz. 150(1(7)), 5–17 (2016)].
37. H. Frohlich, “The biological effects of microwaves and related questions,” Adv. Electron. Electron Phys. 53, 85–152 (1980).
38. J. Pokorny and T.-M. Wu, Biophysical Aspects of Coherence and Biological Order (Springer, Prague, 1998).
39. J. Pokorny, “Biophysical aspects of cancer,” in The 10th International Frohlichs Symposium, Prague, Czech Republic, 2016.
40. E. Yu. Perlin, T. A. Vartanyan, and A. V. Fedorov, Solid State Physics: Optics of Semiconductors, Dielectrics, and Metals (SibGU ITMO, St. Petersburg, 2008).
41. M. K. Sing, Z.-G. Wang, G. H. McKinley, and B. D. Olsen, “Celebrating Soft Matter’s 10th anniversary: chain configuration and rate-dependent mechanical properties in transient networks,” Soft Matter 11, 2085–2096 (2015).
42. S. V. Sazonov, “Terahertz solitons,” J. Opt. Technol. 82(11), 719–726 (2015) [Opt. Zh. 82(11), 5–14 (2015)].