Polyaniline nanoparticles: potential optical coherence tomography contrast agents

Yu, Jianfeng, Liu, Zhiming, Wang, Xinpeng, Jin, Mei, Chen, Haolin, Guo, Zhouyi

Publication in Journal of Optical Technology

For Russian citation (Opticheskii Zhurnal):

Jianfeng Yu, Zhiming Liu, Xinpeng Wang, Mei Jin, Haolin Chen, Zhouyi Guo Polyaniline nanoparticles: potential optical coherence tomography contrast agents [на англ. яз.] // Оптический журнал. 2015. Т. 82. № 9. С. 82–89.

Jianfeng Yu, Zhiming Liu, Xinpeng Wang, Mei Jin, Haolin Chen, Zhouyi Guo Polyaniline nanoparticles: potential optical coherence tomography contrast agents [in English] // Opticheskii Zhurnal. 2015. V. 82. № 9. P. 82–89.

For citation (Journal of Optical Technology):

Jianfeng Yu, Zhiming Liu, Xinpeng Wang, Mei Jin, Haolin Chen, and Zhouyi Guo, "Polyaniline nanoparticles: potential optical coherence tomography contrast agents," Journal of Optical Technology. 82(9), 639-645 (2015). https://doi.org/10.1364/JOT.82.000639

Abstract:

Polyaniline, an organic conducting polymer, exhibits strong light absorption in the near-infrared region. Herein, the potential of polyaniline nanoparticles as the contrast agents for optical coherence tomography imaging was investigated. Polyaniline nanoparticles were synthesized by a facile chemical oxidative method. The optical coherence tomography images obtained from ex vivo swine liver tissues showed the concentration-dependent contrast effect of polyaniline nanoparticles. Then the nanoagents were applied to in vivo optical coherence tomography imaging of tumor tissues using a xenograft tumor mouse model. The penetration depth of the optical coherence tomography signals from tumors injected with polyaniline nanoparticles was significantly lower than that from tumors injected with phosphate buffer solution. The remarkable contrast effect of polyaniline nanoparticles was then quantitatively studied by the attenuation coefficients of optical coherence tomography signals. Furthermore, the permeation dynamics of polyaniline nanoparticles in tissue was also studied by Raman spectroscopy.

Keywords:

polyaniline nanoparticle, optical coherence tomography, Raman spectroscopy

Acknowledgements:

This work was supported by the National Natural Science Foundation of China (No. 61275187; No. 61335011; No.11404116 and No. 31300691), Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20114407110001 and No. 20134407120003), the Science and Technology Project of Guangdong Province (No. 2012A080203008), the Science and Technology Innovation Project of the Education Department of Guangdong Province (No. 2013KJCX0052), and the Scientific Research Cultivation Fund for Young Teachers of South China Normal University (No. 14KJ10).

OCIS codes: 160.4890, 170.1650

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