Preparation and optical properties of gold-polymer hybrids for bioimaging by surface-enhanced Raman scattering

For Russian citation (Opticheskii Zhurnal):

Свинко В.О., Соловьева Е.В. Получение и оптические свойства золото-полимерных гибридов для биовизуализации методом гигантского комбинационного рассеяния света // Оптический журнал. 2024. Т. 91. № 11. С. 91–99. http://doi.org/10.17586/1023-5086-2024-91-11-91-99

Svinko V.O., Solovyeva E.V. Preparation and optical properties of gold-polymer hybrids for bioimaging by surface-enhanced Raman scattering [in Russian] // Opticheskii Zhurnal. 2024. V. 91. № 11. P. 91–99. http://doi.org/10.17586/1023-5086-2024-91-11-91-99

For citation (Journal of Optical Technology):

Abstract:

Subject of study. Hybrid structures based on gold nanoparticles, polymer shell and molecular dye. Aim of study. The study of influence of preparative factors on the optical properties and stability of organic-inorganic hybrids, as well as the testing of resulting three-component systems for bioimaging by surface-enhanced Raman scattering. Method. Gold nanorods were obtained by seed-mediated technique and coated by a multilayer polymer shell with cyanine 5.5 dye covalently conjugated to its surface. Morphology of the nanoparticles was confirmed using transmission electron microscopy and the dispersions stability was assessed by electrophoretic light scattering. The optical properties of hybrid nanostructures were studied by surface-enhanced Raman scattering. Main results. It was found that core-shell structures with a covalently conjugated dye have a more intense spectral response compared to hybrids in which the dye is immobilized by nonspecific sorption. The prepared plasmonic tags are appropriate for contrast cell imaging. Practical significance. The prepared tags based on gold-polymer hybrids have potential for use as optical contrasts in medical diagnostics and photothermal therapy.

Keywords:

tags, gold nanoparticles, surface-enhanced Raman scattering, bioimaging, covalent conjugation

Acknowledgements:

this work was supported by Saint-Petersburg State University, project № 122040800256-8. The study was carried out using the equipment of the Interdisciplinary Resource Centre for Nanotechnology, the Centre for Optical and Laser Materials Research, the Centre for Physical Methods of Surface Investigation.

OCIS codes: 170.5660, 160.4236, 170.3880

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