Potential of “AgInS2 quantum dots/albumin nanoparticles” system for photodynamic therapy

Gorbacheva V.I., Reznik I.A., Kolesova, E.P.

For Russian citation (Opticheskii Zhurnal):

Горбачева В.И., Резник И.А., Колесова Е.П. Потенциал системы «квантовые точки AgInS2/альбуминовые наночастицы» для фотодинамической терапии // Оптический журнал. 2025. Т. 92. № 5. С. 99–109. http://doi.org/10.17586/1023-5086-2025-92-05-99-109

Gorbacheva V.I., Reznik I.A., Kolesova E.P. Potential of “AgInS2 quantum dots/albumin” system for photodynamic therapy [in Russian] // Opticheskii Zhurnal. 2025. V. 92. № 5. P. 99–109. http://doi.org/10.17586/1023-5086-2025-92-05-99-109

For citation (Journal of Optical Technology):

Abstract:

Subject of study. Free and encapsulated in albumin nanoparticles quantum dots AgInS2 and AgInS2/ZnS. Aim of study. Determination and comparison of the fluorescence properties and the ability to generate reactive oxygen species of free quantum dots and quantum dots encapsulated in albumin nanoparticles for use as sensitizers for photodynamic therapy. Method. Quantum dots were synthesized by hydrothermal method, albumin nanoparticles by desolvation method, encapsulation of quantum dots into albumin nanoparticles was carried out by co-incubation in aqueous solution. Superoxide generation efficiency was estimated using selective chemical sensor. Main results. It was demonstrated that the growth of the ZnS shell on the AgInS2 quantum dots leads to an increase in both the fluorescence quantum yield and the efficiency of superoxide generation. The encapsulation efficiency of AgInS2 and AgInS2/ZnS quantum dots in albumin nanoparticles was 60 and 20%, respectively, which was accompanied by a hypsochromic shift in the fluorescence spectra of quantum dots. Encapsulation of quantum dots in albumin nanoparticles led to a decrease in the efficiency of superoxide generation compared to free quantum dots, which can be compensated for by their greater stability in biological systems. Practical significance. The obtained results of the study of the photophysical properties of AgInS2 quantum dots demonstrated the high potential of nanoplatforms based on quantum dots and albumin nanoparticles as sensitizers for photodynamic therapy.

Keywords:

quantum dots, albumin nanoparticles, photoluminescence, reactive oxygen species, photosensitize

Acknowledgements:

this work was supported by the Russian Science Foundation, project № 24-24-20102

OCIS codes: 170.5180, 170.6280

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